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TFP #257 – A rushed introduction to an uninvited guest

Clinical Question: COVID-19: What are the presenting symptoms, clinical course, and risk factors for mortality? Bottom Line: Cough and fever are the most common symptoms. Differences in testing and reporting of cases limit prognostic estimations. At minimum, 80% of cases are clinically mild. Of those hospitalized in North America, ~25% will require ICU admission. Risk factors for…

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TFP #256 -Hydroxychloroquine with or without azithromycin for COVID-19

Clinical Question: Is hydroxychloroquine (with or without azithromycin) effective in treating COVID-19? Bottom Line: One nonrandomized study found that more hydroxychloroquine/azithromycin patients tested negative for virus at days 3 and 6 but clinical outcomes were not reported. One unblinded randomized trial showed no effect from hydroxychloroquine on viral or clinical outcomes. Without further evidence, hydroxychloroquine is not…

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